Trying to get pregnant can feel like a rollercoaster ride, especially if you’re going through fertility treatments. There are so many terms, procedures, and options to learn about, as well as some really fascinating advancements in fertility science, like EmbryoGlue®.

No, it's not the kind of glue you'd find in a craft store! It's actually a special solution used during in vitro fertilization (IVF) to help embryos implant in the uterus. Pretty cool, right?

So, what is EmbryoGlue®?

EmbryoGlue® is a type of culture medium — a special liquid that helps cells grow and thrive. This particular medium is used during the embryo transfer process in IVF. It's designed to mimic the natural fluids found in a woman's uterus, giving the embryo a cozy environment that feels just like home.

If you’re wondering why it's called "glue" if it's actually a liquid — it's not because it's sticky like regular glue. The name comes from its main job: helping the embryo attach to the uterus wall. Think of it more like a welcoming cushion that encourages the embryo to snuggle in and make itself completely comfortable.

reproductive endocrinologist discussing embryoglue with couple

The secret ingredient

EmbryoGlue contains a high concentration of hyaluronan, a natural substance found in many parts of our bodies, including the fluid in our joints and the whites of our eyes. The concentration in EmbryoGlue is much higher than what's found in standard culture media used in IVF.

In the uterus, hyaluronan (also known as hyaluronic acid) plays a crucial role in embryo implantation. This extra boost gives embryos a better chance of sticking around and resulting in a viable pregnancy. EmbryoGlue also contains essential ingredients like proteins, salts, and energy sources that those embryos need to thrive.

How EmbryoGlue works

"Clinical studies have shown that using EmbryoGlue as a transfer medium enhances embryo implantation, leading to higher birth rates. Its specialized formulation, enriched with hyaluronan, provides an added advantage, offering patients a scientifically supported boost on their journey to parenthood."

— Brett Glazar, M.S.

Medical Science Liaison, North America - Vitrolife Group

When an embryo is placed in the uterus during IVF, it needs to attach to the uterus wall to continue developing. This process is called implantation, and it's a crucial step in achieving a successful pregnancy. EmbryoGlue is designed to work in a few different ways to help make this happen:

  • It creates a thick, viscous environment around the embryo to help keep the embryo in place once it's transferred, giving it more time to attach to the uterine lining. 

  • The hyaluronan in EmbryoGlue interacts with special receptors on both the embryo and the uterine lining to help the embryo and uterus recognize each other and form a strong connection.

  • It provides essential nutrients and growth factors that support the embryo's development during those crucial first few days after transfer.

emybryoglue in a petri dish

Does EmbryoGlue really make a difference?

Studies have shown promising results: Some research suggests that using EmbryoGlue can increase the chances of embryo implantation and live birth rates. 

While every person’s fertility journey is different, it’s important to know your options. With a clinically proven, FDA-approved option like EmbryoGlue, your fertility specialist will be able to work with you on decisions to help increase your odds of a successful pregnancy.  

Who can use EmbryoGlue?

While safe for use in the majority of IVF cycles, EmbryoGlue is a chance to ensure the best conditions for the right embryo to implant. 

Some people who might benefit from EmbryoGlue include those who have had or have:

Studies suggest that EmbryoGlue can help support implantation, though you should be aware:

  • If you have an allergy to gentamicin

  • EmbryoGlue may increase the likelihood of multiple gestations (i.e. twins or triplets), and you should consider this possibility.

couple hugging

What else should you know about EmbryoGlue?

If you're considering using EmbryoGlue in your IVF treatment, here are a few more things to keep in mind:

  • Using EmbryoGlue doesn't change the IVF process from your perspective. You won't need any additional procedures or appointments. EmbryoGlue is simply used in the lab when preparing your embryo(s) for transfer.

  • Adding EmbryoGlue may improve your chances of success, and as an FDA-approved solution, it can be a helpful tool in the fertility treatments toolkit. 

  • Depending on insurance and how your clinic handles billing, the cost of EmbryoGlue may vary from provider to provider. Talk to your clinic about payment options, and ask whether your insurance might cover it. 

EmbryoGlue is an exciting development in the world of fertility treatments. By mimicking the natural environment of the uterus and providing extra support for embryos to implant, it’s a valuable FDA-backed option if you’re undergoing IVF. 

The journey to parenthood can be challenging, but you're not alone. New advancements are being made in fertility science, and EmbryoGlue is just one example of how researchers are working to improve IVF success rates. Stay informed, ask questions, and most importantly, don't lose hope! 

Blair Sharp is a freelance writer who lives in Minnesota with her husband and son. Her words have been published in various publications, including Parents, SheKnows, The Bump, and Insider. You can find her watching reality TV and sharing too many reels with her friends when she's not writing. To connect with Blair, find her on LinkedIn and Instagram, or head to her website www.blairsharp.com.