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Women's Health, Your Way

January 17, 2026

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Videos

What Is a Saline Sonogram (SIS)? with Dr. Katherine L. Palmerola of IVFMD

Hi, my name is Dr. Catherine Pomerola and I am one of the fertility specialists at IVFMD in Miami, which is part of the Prelude Network. If you're new to fertility treatments, you may be overwhelmed by the number of abbreviations and different procedures we have during your testing and treatments. So I wanted to explain some of the most common procedures that you may face during your evaluation. Saline-infused Sinohistogram. This also goes by the abbreviation SIS. Actually very similar to the HSG or hysterosopingarrhium in terms of what you will feel, but this is a better test to look at the inside part of the uterus. So the saline test is done by inserting a very small amount of sterile saline, salt water, into the uterus. While we're inserting the fluid, we're using an ultrasound to take pictures and view the inside part of the uterus. So the saline just expands and opens up the uterus a little bit and allows us to see structures within the uterus, such as a polyp or a scar tissue. We might see something called a septum, which is a separation of the two sides of the uterus, and it gives us a better sense of the lining of the uterus.